Not all breast cancers are the same. Understand what type of breast cancer you have and how it differs from other types of breast cancer. Once you've been diagnosed with breast cancer, your doctor will review your pathology report and the results of any imaging tests to understand the specifics of your tumor.
Estrogen receptor modulators and estrogen deprivation have become standards of care for hormone receptor—positive metastatic breast cancer. However, after traditional first-line endocrine monotherapy treatment, the disease typically progresses despite the initial high rate of clinical benefit. Multiple studies have aimed at optimizing treatment strategies to improve upon clinical benefit beyond the traditional single-agent endocrine treatment.
Human epidermal growth factor receptor 2 HER2 proteins are found on the surface of breast cells and are involved in normal cell growth. Too much HER2 protein, however, can cause some types of breast cancer to grow and spread. There are a few differences between HER2-positive and HER2-negative breast cancers, including the tumor's risk factors, its biology, and its anticipated aggressiveness.
Your HER2 status can also help determine how aggressive the cancer is. Your doctor will use this information to evaluate your treatment options. In recent years, there have been significant developments in the treatment of HER2-positive breast cancer.
I believe my oncologist should NOT have placed me on Anastrozole…. I am both ER and PR positive, have had two partial mastectomies in one breast and 25 radiation treatments for Stage 0, grade 3 73 year old with osteopenia and osteoporosis with family history of same bone ailments. I feel the same.
These cancer cells have special proteins inside, called hormone receptors. When hormones attach to hormone receptors, the cancer cells with these receptors grow. A pathologist determines the hormone receptor status by testing the tumor tissue removed during a biopsy. Most about 70 percent breast cancers are hormone receptor-positive [ 39 ].